Реакция #1797493

Уравнение реакции

5-aminoindane

acetic anhydride

→

5-(N-acetylamino)indane

Выход 84.6%

Растворители

—

ice water

acetic acid

Условия реакции

Обработка

1. 1
   workup.ADDITIONAfter completion of the dropwise addition
2. 2
   ДругоеAfter completion of the reaction
3. 3
   Другоеthe reaction liquid
4. 4
   workup.STIRRINGwhile stirring
5. 5
   ДругоеCrystals precipitated
6. 6
   Фильтрацияwere filtered off
7. 7
   Промывкаwashed with 1,000 ml of water
8. 8
   ДругоеThe crystals obtained
9. 9
   Другоеwere dried

Методика

33.3 g (0.25 mol) of 5-aminoindane (a product of Tokyo Chemical Industry Co. Ltd.) was dissolved in 250 ml of glacial acetic acid, the resulting solution was heated to 50° C., and 51.0 g (0.5 mol) of acetic anhydride was added dropwise thereto. After completion of the dropwise addition, the resulting solution was stirred for 4 hours. After completion of the reaction, the reaction liquid was poured in 1,500 ml of ice water while stirring. Crystals precipitated were filtered off, and washed with 1,000 ml of water. The crystals obtained were dried to obtain 37.06 g of 5-(N-acetylamino)indane (yield: 84.6%, melting point: 100.5 to 103.5° C.)

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