Реакция #1794503

Уравнение реакции

dibutyltin oxide

methyl (R)-3-hydroxybutyrate

(R)-3HB

1,4-butanediol

→

titled oligomer

Выход 90.4%

Methyl (R)-3-hydroxy-butyrate 1,4-Butanediol

Выход 90.4%

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONthe mixture was distilled at 130° C. for 3 hours in a nitrogen
2. 2
   Другоеto remove methanol

Методика

In a 200 ml reactor were charged 105.5 g (0.893 mol) of methyl (R)-3-hydroxybutyrate (hereinafter abbreviated as (R)-3HB), 8.05 g (0.0893 mol) of 1,4-butanediol, and 0.45 g (1.80 mmol) of dibutyltin oxide, and the mixture was distilled at 130° C. for 3 hours in a nitrogen stream to remove methanol. The pressure was gradually diminished to 0.5 mmHg, and the reaction mixture was stirred at 140° C. under that reduced pressure for 5 hours to obtain 76.8 g (percent yield: 90.4%) of the titled oligomer.

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