Реакция #1790930

Уравнение реакции

2-amino-2-methyl-1,3-propanediol

cyclohexanone

→

desired compound

3-Methyl-3-Methylol-1-Oxa-4-Azaspiro[4.5]Decane

Растворители

toluene

Условия реакции

Обработка

1. 1
   ДругоеAfter removing the toluene
2. 2
   workup.DISTILLATIONthe residue was distilled

Методика

The procedure of Example 1 was employed utilizing 2-amino-2-methyl-1,3-propanediol (42.05 grams; 0.4 mole) and cyclohexanone (39.26 grams; 0.4 mole) in 250 mls of toluene. After removing the toluene, the residue was distilled to obtain 37.7 grams (50.8% of theoretical; b.p. 120° C. at 2.0 mm.) of the desired compound.

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