Реакция #1790929

Уравнение реакции

Tris-(hydroxymethyl)-aminomethane

cyclohexanone

water

→

desired compound

3,3-Dimethylol-1-Oxa-4-Azaspiro[4.5]Decane

Растворители

toluene

Условия реакции

Обработка

1. 1
   Другоеto remove approximately 3.6 mls of water
2. 2
   ДругоеThe toluene was then removed by distillation
3. 3
   Другоеthe residue was recrystallized from acetone

Методика

Tris-(hydroxymethyl)-aminomethane (24.23 grams; 0.2 mole) and cyclohexanone (19.63 grams; 0.2 mole) were refluxed overnight in 150 mls of toluene, using a water separator to remove approximately 3.6 mls of water. The toluene was then removed by distillation and the residue was recrystallized from acetone to obtain 32 grams (79.5% of theoretical; m.p. 117°-119° C.) of the desired compound.

Источник