Реакция #1782

Уравнение реакции

2-ethyl-3-hydroxymethylpyridine

thionyl chloride

→

2-ethyl-3-chloromethylpyridine

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed under reduced pressure
2. 2
   Другоеthe residue was partitioned between CH2Cl2 (100 mL) and saturated aqueous sodium bicarbonate (100 mL)
3. 3
   СушкаThe organic layer was dried with MgSO4
4. 4
   Фильтрацияfiltered
5. 5
   Другоеthe solvent removed under reduced pressure

Методика

The 2-ethyl-3-hydroxymethylpyridine (2.3 g, 16.8 mmol) was dissolved in CH2Cl2 (100 mL) and cooled under nitrogen to 0° C. and thionyl chloride (7.0 mL) was slowly added and the reaction was stirred for 3 hours. The solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was dried with MgSO4, filtered, and the solvent removed under reduced pressure to give the desired 2-ethyl-3-chloromethylpyridine.

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