Реакция #1772017

Уравнение реакции

compound 4

N-Methyl-3-pyrrolidinyl cyclopentylmandelate

ethyl bromoacetate

ethyl ether

→

Compound ( b )

3-(2-Cyclopentyl-2-phenyl-2-hydroxyacetoxy)-1-(ethoxycarbonylmethyl)-1-methylpyrrolidinium bromide

Растворители

acetonitrile

ethylene chloride

Условия реакции

Обработка

1. 1
   ДругоеEvaporation of acetonitrile
2. 2
   Другоеgave a crude product
3. 3
   Другоеto precipitate

Методика

To compound 4 (0.369 g, 1.22 mmol) in 10 ml of dry acetonitrile, ethyl bromoacetate (0.377 g, 2.25 mmol) was added at room temperature. The mixture was stirred for 2 h. Evaporation of acetonitrile gave a crude product. The crude product was dissolved in a small volume of ethylene chloride and then poured into 50 ml of dry ethyl ether to precipitate. This procedure was repeated three times to obtain Compound (b) as pure product (0.45 g, 79%). White powder, m.p.: 192-194° C.

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