Реакция #1771993

ord-40794a691015423f8f8e6dd4b847146a

Уравнение реакции

CC(C)(C)OC(=O)N1CC(c2ccccc2)C[C@H]1C(=O)O
Boc-4-phenylproline
→
CC(C)(C)OC(=O)N1CC(C2CCCCC2)C[C@H]1C(=O)O
product
Выход 95.4%
CC(C)(C)OC(=O)N1CC(C2CCCCC2)C[C@H]1C(=O)O
Boc-4-cyclohexylproline
Выход 95.4%

Реактанты

CC(C)(C)OC(=O)N1CC(c2ccccc2)C[C@H]1C(=O)O
Boc-4-phenylproline

Реагенты

[Rh]
Rh on carbon

Растворители

CO
methanol

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ФильтрацияThe mixture was filtered
  2. 2
    Концентрированиеconcentrated

Методика

A solution of the commercially available Boc-4-phenylproline (750 mg) and 5% Rh on carbon (750 mg) in methanol (15 mL) was hydrogenated at 50 psi for 24 hours. The mixture was filtered and concentrated to give 730 mg of product.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: USRE043298E1uspto-grants-2012_04