Реакция #1771991

Уравнение реакции

Boc-Pro(4,4-diMe)-OH

thionylchloride

methanol

→

4,4-Dimethylproline Methylester Hydrochloride Salt

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was concentrated to an amorphous solid (377 mg, 95%)

Методика

To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).

Источник