Реакция #1769053

Уравнение реакции

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride

1-propanol

thionyl chloride

→

white crystals

Выход 56.0%

n-Propyl 1,4,5,6-Tetrahydropyrimidine-5-carboxylate Hydrochloride

Выход 56.0%

Условия реакции

Обработка

1. 1
   Температураthe solution was refluxed for 22 h
2. 2
   ДругоеThe solvent was evaporated in vacuo to dryness
3. 3
   ДругоеThe residue was crystallized from methanol/THF

Методика

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride (1.5 g, 9.1 mmol) was dissolved in 1-propanol (30 ml). To the mixture was added thionyl chloride (1.1 g, 9.1 mmol) and the solution was refluxed for 22 h. The solvent was evaporated in vacuo to dryness. The residue was crystallized from methanol/THF to give 1.06 g (56%) of white crystals, mp 128°-130° C. 300 MHz nmr indicated product. Microanalysis calc.: C 46.49, H 7.26, N 13.56, found: C 46.21, H 6.96, N 17.41.

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