Реакция #1756979

Уравнение реакции

methyl 2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]-3-oxobutanoate

4-amino-1-cyclobutylpent-3-en-2-one

→

title compound

Methyl 5-(cyclobutylacetyl)-2,6-dimethyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydro-pyridine-3-carboxylate

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураunder reflux under argon for 24 h
3. 3
   ДругоеThe reaction mixture is purified by preparative HPLC

Методика

50 mg (0.175 mmol) of methyl 2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]-3-oxobutanoate are dissolved with 34.7 mg (0.227 mmol) of 4-amino-1-cyclobutylpent-3-en-2-one in 3 ml of ethanol and heated under reflux under argon for 24 h. The reaction mixture is purified by preparative HPLC. Concentration of the fractions results in 36 mg (43% of theory) of the title compound as a white solid.

Источник