Реакция #1755

Уравнение реакции

water

trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol

potassium carbonate

diethylamine

→

trans-O-Acetyl-4-(4-diethylaminomethylphenyl)-cyclohexanol

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Экстракцияthe mixture is extracted with methylene chloride
2. 2
   ДругоеThe organic phase is dried
3. 3
   Другоеevaporated down in vacuo
4. 4
   Другоеthe residue remaining is purified by column chromatography (aluminium oxide basic, activity stage III, ICN; petroleum ether/ethyl acetate=15:1)

Методика

A solution of 1 g (3.75 mmol) of trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol in 10 ml of dimethylformamide is mixed with 0.52 g (3.75 mmol) of potassium carbonate and 0.27 g (3.75 mmol) of diethylamine. This mixture is heated to 50° C. for 6 hours with stirring, then water is added and the mixture is extracted with methylene chloride. The organic phase is dried, evaporated down in vacuo and the residue remaining is purified by column chromatography (aluminium oxide basic, activity stage III, ICN; petroleum ether/ethyl acetate=15:1). Colourless oil.

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