Реакция #1747867

Уравнение реакции

10-(4-benzyloxyphenyl)phenothiazine 5,5-dioxide

ammonium formate

→

10-(4-Hydroxyphenyl)phenothiazine 5,5-dioxide

Растворители

acetone

Условия реакции

Обработка

1. 1
   Фильтрацияthe solution was filtered
2. 2
   КонцентрированиеThe filtrate was concentrated
3. 3
   workup.ADDITIONafter adding 10 ml of methanol
4. 4
   ФильтрацияThe solid was filtered off with suction
5. 5
   Промывкаwashed with methanol
6. 6
   Другоеdried at 110° C. in a vacuum
7. 7
   Другоеdrying cabinet
8. 8
   Другоеwere obtained

Методика

3.10 g (7.50 mmol) of 10-(4-benzyloxyphenyl)phenothiazine 5,5-dioxide, 2.30 g (35.7 mmol) of 98% ammonium formate and 7.5 g of 10% palladium on activated carbon were heated to boiling under reflux in 225 ml of acetone for 1 hour. After cooling to room temperature, the solution was filtered. The filtrate was concentrated and, after adding 10 ml of methanol, stirred overnight. The solid was filtered off with suction, washed with methanol and dried at 110° C. in a vacuum drying cabinet. 1.47 g (61% of theory) of analytically pure light gray microcrystals having an m.p. of 308-311° C. were obtained.

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