Реакция #1740889

Уравнение реакции

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride

methanol

thionyl chloride

→

white crystals

Выход 60.0%

1,4,5,6-Tetrahydro-5-methoxycarbonylpyrimidine Hydrochloride

Выход 60.0%

Условия реакции

Обработка

1. 1
   ТемператураThe resulting solution was refluxed
2. 2
   workup.STIRRINGwith stirring for 18 hours
3. 3
   Другоеevaporated in vacuo to white solids
4. 4
   ДругоеThe crude product was recrystallized from anhydrous methanol

Методика

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride (6.34 g, 38.5 mmol) was dissolved in anhydrous methanol (200 ml) with stirring, and thionyl chloride (2.74 ml, 38.5 mmol) was added dropwise. The resulting solution was refluxed with stirring for 18 hours, then evaporated in vacuo to white solids. The crude product was recrystallized from anhydrous methanol to yield 4.12 g (60%) white crystals, mp 160°-164° C. Calculated: C 40.34, H 6.21, N 15.69; found: C 40.17, H 6.41, N 15.73.

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