Реакция #1731762

Уравнение реакции

methyl 2,5-dihydroxybenzoate

potassium carbonate

benzyl bromide

→

methyl 5-benzyloxy-2-hydroxybenzoate

Выход 63.0%

Растворители

acetone

Условия реакции

Обработка

1. 1
   ДругоеAfter the insoluble material was removed by filtration
2. 2
   Концентрированиеthe mother solution was concentrated
3. 3
   ДругоеThe obtained residue was purified by column chromatography (LL, Biotage cartridge, ethyl acetate:n-hexane=1:9→1:5)

Методика

To a mixed solution of methyl 2,5-dihydroxybenzoate (10.0 g), potassium carbonate (12.3 g) and acetone (100 ml) was added benzyl bromide (7.43 ml), and the mixture was stirred overnight at room temperature. After the insoluble material was removed by filtration, the mother solution was concentrated. The obtained residue was purified by column chromatography (LL, Biotage cartridge, ethyl acetate:n-hexane=1:9→1:5) to give methyl 5-benzyloxy-2-hydroxybenzoate (9.63 g, 63%) as colorless crystals.

Источник