Реакция #1726730

Уравнение реакции

Acetic acid

N-(3,3-diphenylpropyl)-N-(4-piperidinyl)-N′-[3-(trifluoromethyl)phenyl]urea

→

white foam

Выход 62.0%

N-(1-acetyl-4-piperidinyl)-N-(3,3-diphenylpropyl)-N′-[3-(trifluoromethyl)phenyl]urea

Выход 62.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe mixture is agitated overnight
2. 2
   ФильтрацияThe resin is filtered
3. 3
   Концентрированиеthe filtrate is concentrated
4. 4
   ДругоеThe oil obtained
5. 5
   Промывкаeluting with an equimolar mixture of heptane and ethyl acetate in order

Методика

117 mg (175 μmol, 3.5 eq.) of P-EDC resin is preswollen in 1.5 ml of anhydrous dichloromethane. Acetic acid (7.5 mg, 125 μmol, 2.5 eq.) is added and the mixture is agitated for 10 minutes. Then N-(3,3-diphenylpropyl)-N-(4-piperidinyl)-N′-[3-(trifluoromethyl)phenyl]urea (24.3 mg, 50 μmol) is added in its turn and the mixture is agitated overnight. The resin is filtered and the filtrate is concentrated. The oil obtained is passed through a silica gel cartridge eluting with an equimolar mixture of heptane and ethyl acetate in order to obtain 16 mg (yield=62%) of a white foam after concentration.

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