Реакция #1726728

Уравнение реакции

trifluoroacetic acid

tert-butyl 4-((3,3-diphenylpropyl) {[3-(trifluoromethyl)anilino]carbonyl}amino)-1-piperidine carboxylate

→

white foam

Выход 98.0%

N-(3,3-diphenylpropyl)-N-(4-piperidinyl)-N′-[3-(trifluoromethyl)phenyl]urea

Выход 98.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Концентрированиеthen concentrated
2. 2
   workup.ADDITIONDichloromethane is added
3. 3
   Промывкаthe organic phase is washed with a saturated solution of sodium bicarbonate
4. 4
   Сушкаdried over magnesium sulphate
5. 5
   Фильтрацияfiltered
6. 6
   Концентрированиеconcentrated under vacuum in order

Методика

1.6 ml (21 mmol, 20 eq.) of trifluoroacetic acid is added to a solution of tert-butyl 4-((3,3-diphenylpropyl) {[3-(trifluoromethyl)anilino]carbonyl}amino)-1-piperidine carboxylate (600 mg, 1.04 mmol) in dichloromethane. The reaction medium is agitated for 90 minutes then concentrated. Dichloromethane is added and the organic phase is washed with a saturated solution of sodium bicarbonate, dried over magnesium sulphate, filtered and concentrated under vacuum in order to isolate 490 mg (yield=98%) of a white foam.

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