Реакция #1726725

Уравнение реакции

solution

1-(3-fluorophenyl)-3-(2-methyl-4-nitrophenyl)urea

hydrogen

→

1-(4-amino-2-methylphenyl)-3-(3-fluorophenyl)urea

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   ФильтрацияThe mixture was filtered
2. 2
   Экстракцияthe filtrate was extracted with ethyl acetate
3. 3
   ЭкстракцияThe organic extract
4. 4
   Промывкаwas washed with brine
5. 5
   Сушкаdried with MgSO4
6. 6
   Концентрированиеconcentrated
7. 7
   Другоеto provide EXAMPLE 100B

Методика

A solution of EXAMPLE 100A (1.28 g, 4.43 mmol) in 12 mL of N,N-dimethylformamide was degassed and hydrogenated under an atmosphere of hydrogen (balloon) in the presence of catalytic amount of 10% Pd on carbon for 24 hours. The mixture was filtered and the filtrate was extracted with ethyl acetate. The organic extract was washed with brine, dried with MgSO4 and concentrated to provide EXAMPLE 100B. MS (ESI(+)) m/e 260 (M+H)+.

Источник