Реакция #1726719

Уравнение реакции

2-benzyloxy-5-(1H-tetrazol-5-yl)benzamide

ammonium hydroxide

→

2-hydroxy-5-(1H-tetrazol-5-yl)benzamide

Выход 98.1%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe reaction mixture is filtered
2. 2
   Концентрированиеthe filtrate concentrated

Методика

A suspension of 400 mg (1.04 mmol) of 2-benzyloxy-5-(1H-tetrazol-5-yl)benzamide and 500 mg of 10% Pd/C (50% water) in 2 mL of methanol containing 1 mL of 28% aqueous ammonium hydroxide is stirred under hydrogen at 48 psi for 24 hr. The reaction mixture is filtered and the filtrate concentrated to give 210 mg (1.02 mmol, 98% yield) of 2-hydroxy-5-(1H-tetrazol-5-yl)benzamide.

Источник