Реакция #1726715

Уравнение реакции

methyl 4-benzyloxy-3-carbamoylbenzoate

hydrogen

→

methyl 3-carbamoyl-4-hydroxybenzoate

Выход 96.4%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe reaction mixture is filtered
2. 2
   Промывкаthe catalyst is repeatedly washed with 10% MeOH/DCM
3. 3
   ДругоеThe combined filtrates are evaporated to dryness

Методика

Hydrogenolysis is effected by dissolving 1.2 gm (4.2 mmol) of methyl 4-benzyloxy-3-carbamoylbenzoate in 60 mL of methanol (warmed to effect solution), adding 1 gm of 10% Pd/C (50% water) catalyst, and stirring under 48 psi of hydrogen overnight at room temperature. The reaction mixture is filtered, and the catalyst is repeatedly washed with 10% MeOH/DCM. The combined filtrates are evaporated to dryness to give 0.79 gm (4.05 mmol, 96% yield) of methyl 3-carbamoyl-4-hydroxybenzoate.

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