Реакция #1726706

Уравнение реакции

2-(N-Boc-amino)-3-phenyl-thiophene

N-chlorosuccinimide

→

2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene

Выход 66.6%

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеat 0° C.
2. 2
   Промывкаwashed with water
3. 3
   Концентрированиеthe organic phase concentrated in vacuo

Методика

To 2-(N-Boc-amino)-3-phenyl-thiophene (89 mg, 0.32 mmol) in dichloromethane (4 ml) at 0° C. was slowly added N-chlorosuccinimide (48 mg, 0.36 mmol), and the mixture allowed warm to ambient temperature for 16 hr. The mixture was diluted with dichloromethane, washed with water, and the organic phase concentrated in vacuo. Flash chromatography on silica gel (ethyl acetate/hexanes) yielded 2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene (66 mg, 66%).

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