Реакция #1726705

Уравнение реакции

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole

phosphoric acid

ammonium hydroxide

→

5-amino-1-(3′-nitrophenyl)-pyrazole

Выход 80.0%

Условия реакции

Обработка

1. 1
   ЭкстракцияThe organics were extracted three times with diethyl ether (total 40 ml)
2. 2
   Промывкаwashed with brine
3. 3
   Сушкаdried over magnesium sulfate
4. 4
   ДругоеRemoval of solvent

Методика

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole (559 mg, 2.44 mmol) and phosphoric acid (86%, 6 ml) were refluxed at 170° C. for 15 h. The reaction was cooled to room temperature and neutralized with ammonium hydroxide. The organics were extracted three times with diethyl ether (total 40 ml), washed with brine, and dried over magnesium sulfate. Removal of solvent gave 5-amino-1-(3′-nitrophenyl)-pyrazole as a yellow powder (398 mg, 80% yield).

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