Реакция #1721763

Уравнение реакции

water

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

hydroxybenzotriazole

8-chloro-6,11-dihydro-11-(1-piperazinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

urocanic acid

→

title compound

1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-4-[(E)-3-(1H-imidazol-4-yl)-1-oxo-2-propenyl]piperazine

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   workup.DISSOLUTIONdissolved (˜10 min.)
2. 2
   workup.STIRRINGto stir at room temperature for 18.5 h
3. 3
   workup.STIRRINGthe solution was stirred briefly
4. 4
   Концентрированиеbefore concentrating under reduced pressure
5. 5
   ДругоеThe residual oil was partitioned between dichloromethane (100 mL) and water (100 mL)
6. 6
   ЭкстракцияThe organic extract
7. 7
   Сушкаwas dried by filtration through anhydrous magnesium sulfate and solvent
8. 8
   Другоеremoved under reduced pressure
9. 9
   ДругоеThe residue was chromatographed on silica gel
10. 10
    Промывкаeluting with dichloromethane-methanol-concentrated ammonium hydroxide (90:9:0.5)

Методика

To a suspension of urocanic acid (1.38 g; 10.0 mmol) (from Aldrich Chemicals) in N,N-dimethylformamide (175 mL) under an inert atmosphere, was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.92 g; 10.0 mmol) and hydroxybenzotriazole (1.08 g; 8 mmol). The resultant mixture was warmed to 40° C. and stirring continued until all solids dissolved (˜10 min.). To the resultant solution was added 8-chloro-6,11-dihydro-11-(1-piperazinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (8) (2.51 g; 8.0 mmol), and the resultant solution was allowed to stir at room temperature for 18.5 h. Then water (250 microliters; 13.9 mmol) was added, and the solution was stirred briefly before concentrating under reduced pressure. The residual oil was partitioned between dichloromethane (100 mL) and water (100 mL). The organic extract was dried by filtration through anhydrous magnesium sulfate and solvent removed under reduced pressure. The residue was chromatographed on silica gel, eluting with dichloromethane-methanol-concentrated ammonium hydroxide (90:9:0.5), to obtain the title compound as a yellow powder that decomposed to a frothy gum at 160° C. SIMS: 434 (MH+; 50%).

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