Реакция #1720

Уравнение реакции

hydrochloric acid

4-amino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide

acetaldehyde

sodium cyanoborohydride

→

4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide

Растворители

methanol

Условия реакции

Методика

A solution of 6 g of 4-amino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide and 0.5 g of titanium tetrachloride in 100 ml of methanol is treated with 1 ml of freshly distilled acetaldehyde. 4 g of sodium cyanoborohydride are then added thereto and the mixture is stirred for 30 hours. Cold half-concentrated hydrochloric acid is added thereto, the mixture is worked up in the customary manner and 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide is obtained.

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