Реакция #170918

Уравнение реакции

1-(Benzo[d][1,3]dioxol-5-yl)-N-(3-bromo-4-methylphenyl)cyclopropanecarboxamide

4-(hydroxymethyl)phenylboronic acid

K2CO3

→

1-(benzo[d][1,3]dioxol-5-yl)-N-(4′-(hydroxymethyl)-6-methylbiphenyl-3-yl)cyclopropanecarboxamide

Выход 59.0%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   ДругоеThe volatiles were removed in vacuo and residue
2. 2
   workup.DISSOLUTIONwas redissolved in dichloromethane (100 mL)
3. 3
   ПромывкаThe organics were washed with 1N HCl (100 mL×2)
4. 4
   Сушкаdried over Na2SO4
5. 5
   Другоеevaporated
6. 6
   ДругоеThe crude product was purified by chromatography on silica gel

Методика

1-(Benzo[d][1,3]dioxol-5-yl)-N-(3-bromo-4-methylphenyl)cyclopropanecarboxamide (3.0 g, 8.1 mmol), 4-(hydroxymethyl)phenylboronic acid (1.5 g, 9.7 mmol), 1 M K2CO3 (16 mL, 16 mmol), Pd-FibreCat 1007 (640 mg), and N,N-dimethylformamide (80 mL) were combined. The mixture was heated at 80° C. for 3 h. The volatiles were removed in vacuo and residue was redissolved in dichloromethane (100 mL). The organics were washed with 1N HCl (100 mL×2), then dried over Na2SO4 and evaporated. The crude product was purified by chromatography on silica gel to afford 1-(benzo[d][1,3]dioxol-5-yl)-N-(4′-(hydroxymethyl)-6-methylbiphenyl-3-yl)cyclopropanecarboxamide (1.9 g, 59%). ESI-MS m/z calc. 401.5. found 402.5 (M+1)+; retention time 3.18 minutes.

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