Реакция #170345

Уравнение реакции

(5-methyl-3-phenyl-isoxazol-4-yl)-methanol

1′-methyl-1′,2′,3′,6′-tetrahydro-1H-[4,4′]bipyridinyl-2-one

→

title compound

Выход 17.0%

1-Methyl-2′-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-1,2,3,6-tetrahydro-[4,4′]bipyridinyl

Выход 17.0%

Условия реакции

Методика

As described for example 4, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (135 mg, 0.72 mmol) was converted using 1′-methyl-1′,2′,3′,6′-tetrahydro-1H-[4,4′]bipyridinyl-2-one instead of 2-hydroxy-5-trifluoromethylpyridine to the title compound (SiO2, heptane:ethyl acetate:methanol=95:5:0 to 0:80:20, 45 mg, 17%) which was obtained as a yellow oil. MS: m/e=362.3 [M+H]+.

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