Реакция #170283

Уравнение реакции

HCl

1-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one

→

title compound

Выход 71.3%

3-(3-chloro-2-hydroxypropoxy)-1-methoxy-9H-xanthen-9-one

Выход 71.3%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Другоеthe reaction solvent was removed under reduced pressure
2. 2
   workup.ADDITIONEther was added to the residue
3. 3
   Другоеfollowed by sonication
4. 4
   Другоеthe solvent was removed

Методика

Aqueous ethyl acetate 1M-HCl (3 mL) was added to 1-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one (25 mg, 0.08 mmol) prepared in Step 4 of Example 9, followed by stirring at room temperature for 30 minutes, and the reaction solvent was removed under reduced pressure. Ether was added to the residue, followed by sonication, and the solvent was removed to give the title compound (20 mg, 71.3%) as a reddish brown solid.

Источник