Реакция #1702076

Уравнение реакции

sodium bicarbonate

5-cyclopropyl-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one

magnesium trifluoromethanesulfonate

2-(phenoxymethyl)oxirane

→

desired compound

Выход 65.0%

5-cyclopropyl-1-(2-hydroxy-3-phenoxypropyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one

Выход 65.0%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling to room temperature
2. 2
   Экстракцияthe mixture was extracted with dichloromethane
3. 3
   ФильтрацияThe organic phases were filtered through a pad of sodium sulfate
4. 4
   Другоеthe filtrate evaporated

Методика

To a mixture of 5-cyclopropyl-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one (50.0 mg, 0.203 mmol) from Example 1 and magnesium trifluoromethanesulfonate (32.7 mg, 0.102 mmol) in acetonitrile (1.5 ml) was added 2-(phenoxymethyl)oxirane (30.5 mg, 0.203 mmol) and the resulting mixture was stirred at 75° C. for 100 hours. After cooling to room temperature was added sodium bicarbonate (saturated aqueous) and the mixture was extracted with dichloromethane. The organic phases were filtered through a pad of sodium sulfate and the filtrate evaporated. Preparative thin layer chromatography (EtOAc/MeOH: 95/5) of the obtained residue, gave the desired compound as a brown oil (52 mg, 65%).

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