Реакция #1702046

Уравнение реакции

Water

CDI

(R)-[4-(3-Oxo-cyclopentyl)-phenoxy]-acetic acid

Ammonium hydroxide

→

title compound

Выход 81.0%

2-[4-[(1R)-3-Oxocyclopentyl]phenoxy]acetamide

Выход 81.0%

Растворители

DMF

Условия реакции

Обработка

1. 1
   Другоеa precipitate formed
2. 2
   Фильтрацияthe precipitate filtered off
3. 3
   Другоеdried in vacuo

Методика

(R)-[4-(3-Oxo-cyclopentyl)-phenoxy]-acetic acid (preparation 31) (1.6 mmol, 375 mg) was dissolved in DMF (3 mL), then CDI (1.84 mmol, 299 mg) was added and the reaction mixture stirred at r.t. for 90 min. Ammonium hydroxide (25% aq, 7 mL) was added and a precipitate formed. Water (7 mL) was added and the precipitate filtered off and dried in vacuo to yield the title compound (302 mg, 81%). 1H NMR (300 MHz, CDCl3) δ 7.25-7.14 (m, 2H), 6.97-6.83 (m, 2H), 6.78 (bs, 1H), 5.91 (bs, 1H), 4.49 (s, 2H), 3.52-3.28 (m, 1H), 2.77-2.57 (m, 1H), 2.57-2.11 (m, 5H), 2.09-1.79 (m, 1H).

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