Реакция #169966

Уравнение реакции

SOCl2

2,6-difluoro-4-hydroxybenzoic acid

MeOH

→

title compound

Выход 99.0%

Methyl 2,6-difluoro-4-hydroxybenzoate

Выход 99.0%

Условия реакции

Обработка

1. 1
   Температураthe resulting mixture was heated
2. 2
   Температураat reflux for 24 h
3. 3
   ТемператураAfter cooling the solvent
4. 4
   Другоеwas removed in vacuo

Методика

SOCl2 (4.16 g, 30.1 mmol) was added to a solution of 2,6-difluoro-4-hydroxybenzoic acid (1.50 g, 8.62 mmol) in MeOH (20 mL) and the resulting mixture was heated at reflux for 24 h. After cooling the solvent was removed in vacuo to give the title compound (1.62 g, 99%) as a white crystalline solid; mp 177.5-180° C.; 1H NMR (270 MHz, DMSO-d6) 3.80 (3H, s, CH3), 6.50-6.60 (2H, m, ArH), 11.16 (1H, s, OH)

Источник