Реакция #169636

Уравнение реакции

2-chloropyridine-4-methanol

thionyl bromide

→

4-(bromomethyl)-2-chloropyridine

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеthe reaction was quenched with saturated aqueous ammonium chloride
2. 2
   ПромывкаThe organic solution was washed 2× with water
3. 3
   Сушкаdried over sodium sulfate
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated in vacuo

Методика

To a solution of 2-chloropyridine-4-methanol (1.02 g, 7.10 mmol) in 15 mL of dichloromethane was added thionyl bromide (1.77 g, 8.53 mmol) dropwise. After 15 min, the reaction was quenched with saturated aqueous ammonium chloride. The organic solution was washed 2× with water, dried over sodium sulfate, filtered, and concentrated in vacuo to provide 4-(bromomethyl)-2-chloropyridine that gave a mass ion (ES+) of 208.0 for [M+H]+.

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