Реакция #169435

Уравнение реакции

4-chloro-7H-pyrrolo[2,3-d]pyrimidine

N-iodosuccinimide

→

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

Выход 79.0%

Растворители

DCM

Условия реакции

Обработка

1. 1
   workup.ADDITIONAfter addition
2. 2
   ФильтрацияThe solid was filtered
3. 3
   Промывкаwashed with water (250 mL), MeOH (280 mL) and CH2Cl2 (280 mL) sequentially
4. 4
   ДругоеThe solid was dried under vacuum

Методика

To a suspension of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (70.5 g, 0.45 mol) in DCM (1.8 L) was added N-iodosuccinimide (120 g, 0.54 mol) in portions. After addition, the mixture was stirred at room temperature overnight. The solid was filtered and washed with water (250 mL), MeOH (280 mL) and CH2Cl2 (280 mL) sequentially. The solid was dried under vacuum to afford 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine as a brown solid in 79% yield, 107 g.

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