Реакция #1689

Уравнение реакции

HCl

phenethylamine

triethylamine

methyl chloroformate

→

title compound

Выход 95.0%

N-Methoxycarbonylphenethylamine

Выход 95.0%

Растворители

diethyl ether

THF

THF

Условия реакции

Обработка

1. 1
   ПромывкаThe organic layer was washed with water
2. 2
   Сушкаdried (MgSO4)
3. 3
   Фильтрацияfiltered
4. 4
   Концентрированиеthe filtrate was concentrated in vacuo

Методика

To a stirred solution of phenethylamine (75.2 mL, 0.6 mol) and triethylamine (83 mL, 0.6 mol) in THF (500 mL) was added slowly methyl chloroformate 46.2 mL, 0.6 mol) dissolved in THF (50 mL). After the reaction was stirred for an additional 1 h at room temperature, diethyl ether (2 L) and 1N HCl (800 mL) were added. The organic layer was washed with water, dried (MgSO4), filtered, and the filtrate was concentrated in vacuo to give a clear oil of pure title compound (102 g, 95%).

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