Реакция #1687622

Уравнение реакции

12

2-Methyl-5-(3-pyridyl)-2H-tetrazole

hydrogen chloride

→

title product

Выход 26.0%

2-Methyl-(3-piperidyl)-2H-tetrazole, hydrochloride

Выход 26.0%

Растворители

acetone

ether

Условия реакции

Обработка

1. 1
   Другоеuntil acidic reaction
2. 2
   ФильтрацияThe precipitate was filtered off
3. 3
   Другоеdried
4. 4
   workup.DISSOLUTIONdissolved in methanol (25 ml)
5. 5
   workup.ADDITION5% palladium on charcoal (0.6 g) was added
6. 6
   ФильтрацияThe catalyst was filtered off
7. 7
   Другоеthe filtrate was evaporated to dryness
8. 8
   ДругоеCrystallization from ethanol

Методика

To a solution of 12 (1.93 g, 0.012 mol) in acetone (50 ml) was added hydrogen chloride in ether until acidic reaction. The precipitate was filtered off, dried, and dissolved in methanol (25 ml). 5% palladium on charcoal (0.6 g) was added, and the mixture was shaked overnight under 3 atm. of hydrogen pressure. The catalyst was filtered off and the filtrate was evaporated to dryness. Crystallization from ethanol yielded 0.63 g (0.0031 mol, 26%) of title product M.P. 168°-172° C. Anal. (C7H14ClN5) C, H, N.

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