Реакция #168581

Уравнение реакции

6-chloropurine

(R)-2-[(E)-2-(3-chlorophenyl)vinyl]-pyrrolidine

triethylamine

→

6-[(R)-2-((E)-2-(3-chlorophenyl)vinyl)pyrrolidin-1-yl]-9H-purine

Выход 16.5%

Растворители

1-butanol

Условия реакции

Обработка

1. 1
   ДругоеFor work-up, the batch is partitioned between ethyl acetate and water
2. 2
   Сушкаthe organic phase is dried over sodium sulfate
3. 3
   Фильтрацияfiltered off
4. 4
   Другоеevaporated in vacuo
5. 5
   ДругоеThe residue is purified by chromatography

Методика

695 mg of 6-chloropurine and 850 mg of (R)-2-[(E)-2-(3-chlorophenyl)vinyl]-pyrrolidine are dissolved in 20 ml of 1-butanol and warmed at 130° C. in the microwave for 6 h with 3.1 ml of triethylamine. For work-up, the batch is partitioned between ethyl acetate and water, the organic phase is dried over sodium sulfate, filtered off and evaporated in vacuo. The residue is purified by chromatography, giving 220 mg of 6-[(R)-2-((E)-2-(3-chlorophenyl)vinyl)pyrrolidin-1-yl]-9H-purine (“A11”); Rt: 1.778 min; [M+H]+326.2; m.p. 194-196°;

Источник