Реакция #1683

Уравнение реакции

trifluoroacetic acid

Boc-D-Phe-Pro-OBn

anisole

→

white powder

Выход 85.0%

D-Phe-Pro-OBn.TFA

Выход 85.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеthe solvents were evaporated in vacuo
2. 2
   workup.DISSOLUTIONthe thick oily residue was dissolved in diethyl ether (1.5 L)
3. 3
   Другое(72 hours)
4. 4
   ФильтрацияThe white precipitate was filtered
5. 5
   Промывкаwashed with diethyl ether (300 mL)
6. 6
   Другоеdried

Методика

To a stirring solution of Boc-D-Phe-Pro-OBn (68 g, 150 mmol) in dichloromethane (50 mL) at 0° C., was added anisole (20 mL) followed by trifluoroacetic acid (400 mL). After stirring for 3 hours, the solvents were evaporated in vacuo and the thick oily residue was dissolved in diethyl ether (1.5 L) and refrigerated (72 hours). The white precipitate was filtered, washed with diethyl ether (300 mL) and dried to yield 59.4 g (85%) of white powder.

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