Реакция #1678

Уравнение реакции

2-bromo-p-chloroacetophenone

methoxythiocarbonylhydrazine

→

5-(4-chlorophenyl)-3H,6H-1,3,4-thiadiazin-2-one

Выход 48.4%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураwas refluxed overnight
2. 2
   Температураcooled
3. 3
   Фильтрацияfiltered
4. 4
   ПромывкаThe light yellow solid was washed with hexane
5. 5
   Другоеdried

Методика

A mixture of 2-bromo-p-chloroacetophenone (9.16 g), methoxythiocarbonylhydrazine (13.0 g) and acetonitrile (75 ml) was refluxed overnight and then cooled and filtered. The light yellow solid was washed with hexane and dried yielding 5-(4-chlorophenyl)-3H,6H-1,3,4-thiadiazin-2-one (4.3 g).

Источник