Реакция #167353

Уравнение реакции

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

5-bromo-1-methyl-1H-indole

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

Выход 27.0%

1-(1-Methyl-1H-indol-5-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

Выход 27.0%

Растворители

1,4-dioxane

Условия реакции

Обработка

1. 1
   Другоеto afford the crude product
2. 2
   ДругоеPurification by column chromatography on silica gel (2% MeOH in CHCl3)
3. 3
   Другоеfollowed by recrystallization

Методика

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.847 mmol) was reacted with 5-bromo-1-methyl-1H-indole (215 mL, 1.016 mmol), 1,4-dioxane (20 mL), copper iodide (15 mg, 0.084 mmol), trans-1,2-diamino cyclohexane (0.03 mL, 0.254 mmol) and potassium carbonate (230 mg, 1.69 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in CHCl3), followed by recrystallization using DCM and hexane afforded 55 mg of the product (27% yield).

Источник