Реакция #1671838

Уравнение реакции

water

4-Phenyl-2,3-dihydro-1H-2-imidazolone

sodium hydride

N-trifluoroacetyl-indoline-5-sulfonylchloride

→

4-phenyl-1-(N-trifluoroacetylindoline-5-sulfonyl)-2-imidazolone

Выход 70.0%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Другоеprepared in Preparation 2
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature for 4 hours
3. 3
   Температураcooled down again to 0° C.
4. 4
   Другоеwas formed
5. 5
   ДругоеThe resulting precipitate was collected
6. 6
   Промывкаwashed with water
7. 7
   Другоеdried

Методика

4-Phenyl-2,3-dihydro-1H-2-imidazolone (4 g, 24.84 mmol) prepared in Preparation 1 was suspended in 30 ml of dimethylformamide and cooled down to 0 ° C. After sodium hydride (60% oily, 1.09 g, 27.3 mmol) was added thereto, the resulting mixture was stirred for a few minutes at 0° C. until it became a clear solution. To the reaction mixture was added portionwise at 0° C. the N-trifluoroacetyl-indoline-5-sulfonylchloride (8.56 g, 27.32 mmol) prepared in Preparation 2. The reaction mixture was stirred at room temperature for 4 hours, cooled down again to 0° C., and then water was slowly added to the mixture until precipitate was formed. The resulting precipitate was collected, washed with water, and dried to afford 7.6 g of 4-phenyl-1-(N-trifluoroacetylindoline-5-sulfonyl)-2-imidazolone.

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