Реакция #166438

Уравнение реакции

1-Benzyl-3-iodo-4-nitro-1H-indazole

Ammonium chloride

→

1-benzyl-3-iodo-1H-indazol-4-amine

Выход 99.9%

Растворители

ethanol

water

ethyl acetate

Условия реакции

Обработка

1. 1
   Температураto cool
2. 2
   Фильтрацияfiltered through a pad of Celite
3. 3
   КонцентрированиеThe solution was concentrated under reduced pressure

Методика

1-Benzyl-3-iodo-4-nitro-1H-indazole (340 mg; 0.897 mmol) was dissolved in a mixture of ethanol (8 mL) and water (2 mL). Ammonium chloride (24 mg; 0.45 mmol) and iron powder (501 mg; 8.97 mmol) were added and the mixture was stirred with heating to 75° C. under a nitrogen atmosphere for 4 hours. The mixture was allowed to cool, diluted with ethyl acetate (50 mL) and filtered through a pad of Celite. The solution was concentrated under reduced pressure to give 1-benzyl-3-iodo-1H-indazol-4-amine (313 mg) as a pale yellow oil.

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