Реакция #166388

Уравнение реакции

2-chloro-5-(chloromethyl)pyridine

potassium carbonate

1-(ethoxycarbonylmethyl)piperazine

→

compound 348

Выход 30.8%

Ethyl 2-(4-((6-chloropyridin-3-yl)methyl)piperazin-1-yl)acetate

Выход 30.8%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ФильтрацияThe mixture was filtered through celite
2. 2
   Промывкаthe filter cake was washed with ethyl acetate
3. 3
   КонцентрированиеThe filtrate was concentrated in vacuo

Методика

To a stirred suspension of 2-chloro-5-(chloromethyl)pyridine (2.0 g, 12 mmol) in acetonitrile (60 mL) was added potassium carbonate (1.5 mL, 25 mmol) followed by 1-(ethoxycarbonylmethyl)piperazine (2.0 mL, 12 mmol). The resulting mixture was stirred at room temperature for 19 h. The mixture was filtered through celite and the filter cake was washed with ethyl acetate. The filtrate was concentrated in vacuo and the residue was subjected to combi-flash column chromatography (methanol/DCM with Et3N) to give compound 348 (1.1 g, 30% yield) as a colorless liquid. 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 8.31 (1 H, d, J=2.0 Hz), 7.66 (1 H, d, J=6.1 Hz), 7.28 (1 H, d, J=8.1 Hz), 4.18 (2 H, q, J=7.1 Hz), 3.50 (2 H, br. s.), 3.21 (2 H, s), 2.36-2.77 (8 H, m), 1.27 (3 H, t, J=7.2 Hz). LCMS-ESI (POS), M/Z, M+1: Found 298.1.

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