Реакция #165954

Уравнение реакции

2-bromo-5-fluoroisonicotinic acid

thionyl dichloride

methanol

→

methyl 2-bromo-5-fluoroisonicotinate

Выход 81.0%

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed under high vacuum
2. 2
   workup.DISTILLATIONThe residual solid was distilled at 90° C. under vacuum

Методика

To a solution of 2-bromo-5-fluoroisonicotinic acid (1.5 g, 6.82 mmol) in methanol (75 ml), thionyl dichloride (2.5 ml, 34.09 mmol) was added drop-wise. The reaction mixture was stirred overnight. The solvent was removed under high vacuum. The residual solid was distilled at 90° C. under vacuum to get 1.3 g (81%) of pure methyl 2-bromo-5-fluoroisonicotinate:

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