Реакция #165778

Уравнение реакции

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

desired product

Выход 69.1%

3-amino-6-bromo-N-(phenylcarbonyloxy)pyrazine-2-carboximidamide

Выход 69.1%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated in vacuo
2. 2
   ДругоеThe resultant residue was triturated with methanol

Методика

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (890 mg, 3.836 mmol) was suspended in dichloromethane (11.56 mL) and treated with triethylamine (427.0 mg, 588.2 μL, 4.220 mmol) followed by benzoyl chloride (593.2 mg, 489.8 μL, 4.220 mmol) The reaction mixture was allowed to stir for 1 hour and concentrated in vacuo. The resultant residue was triturated with methanol to give the desired product as a pale beige solid (891 mg, 69% Yield). 1H NMR (400.0 MHz, DMSO) d 7.55 (2H, m), 7.65 (1H, m), 7.90 (2H, br s), 8.28 (2H, m), 8.33 (1H, s); MS (ES+) 337.87

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