Реакция #165752

Уравнение реакции

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

→

resultant product

Выход 87.0%

5-bromo-3-(5-phenyl-1,2,4-oxadiazol-3-yl)pyrazin-2-amine

Выход 87.0%

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеquenched with NaHCO3

Методика

A mixture of 3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide (575 mg, 1.711 mmol) and polyphosphonic acid (2.300 mL) was heated at 70° C. for 3.5 hours. The resultant solution was diluted with water (20 mL), quenched with NaHCO3 and the resultant product isolated by filtration (475 mg, 87% Yield) as a fawn solid.

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