Реакция #165751

Уравнение реакции

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

product

Выход 70.0%

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

Выход 70.0%

Растворители

DCM

Условия реакции

Обработка

1. 1
   workup.ADDITIONwere added
2. 2
   Другоеthe solvent was removed in vacuo
3. 3
   Другоеthe residue triturated with MeOH
4. 4
   ФильтрацияThe resultant filtrate was filtered off

Методика

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (770 mg, 3.318 mmol) was suspended in DCM (10 mL) and triethylamine (369.3 mg, 508.7 μL, 3.650 mmol) followed by benzoyl chloride (513.1 mg, 423.7 μL, 3.650 mmol) were added. After 1 hour, the solvent was removed in vacuo and the residue triturated with MeOH. The resultant filtrate was filtered off to furnish the product as an off-white solid (779 mg, 70% Yield).

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