Реакция #164574

Уравнение реакции

methyl 2-chloro-5-nitroisonicotinate

Intermediate 26A

methyl 2-chloro-5-nitroisonicotinate

1,4-diazabicyclo[3.2.2]nonane

triethylamine

→

methyl 2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-5-nitroisonicotinate

Растворители

methanol

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was concentrated
2. 2
   Другоеpurified by a 10 g silica column
3. 3
   Промывкаeluting with 40% ethylacetate in hexane

Методика

To a solution of methyl 2-chloro-5-nitroisonicotinate (Intermediate 26A) (0.1 g, 0.46 mmol) in methanol (3 mL) under nitrogen was added 1,4-diazabicyclo[3.2.2]nonane (0.18 g, 0.55 mmol) and triethylamine (7 mg, 0.69 mmol), reaction then stirred overnight. The reaction mixture was concentrated and purified by a 10 g silica column eluting with 40% ethylacetate in hexane to afford methyl 2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-5-nitroisonicotinate.

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