Реакция #1637

Уравнение реакции

(S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

benzyl bromide

sodium carbonate

→

title compound

(S)-N-Benzyl-1(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   ФильтрацияThe mixture was filtered
2. 2
   Промывкаthe residue was washed with ethyl acetate
3. 3
   Промывкаwashed with water and brine
4. 4
   Другоеdried
5. 5
   Другоеevaporated
6. 6
   ДругоеPurification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane)

Методика

A solution of (S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol (1.9 g, 4.8 mMol) and benzyl bromide (0.57 ml, 4.8 mMol) in dimethylformamide (10 ml) containing sodium carbonate (770 mg, 7.2 mMol) was stirred at room temperature for 18 hours. The mixture was filtered and the residue was washed with ethyl acetate. The filtrates were combined, washed with water and brine, dried and evaporated. Purification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane) gave the title compound.

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