Реакция #162888

Уравнение реакции

Boc-Tle-OH

EDCI

DIPEA

benzyl alcohol

→

title compound

Выход 99.0%

(S)-benzyl 2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

Выход 99.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ПромывкаThe mixture was washed several times with an aqueous solution of 5% citric acid
2. 2
   СушкаThe organic layer was dried over sodium sulfate
3. 3
   Фильтрацияfiltered
4. 4
   workup.DISTILLATIONdistilled under reduced pressure

Методика

Boc-Tle-OH (4.8 g, 22.3 mmol) was dissolved in dichloromethane (50 mL), and EDCI (4.3 g, 44.6 mmol), DMAP (0.6 g, 4.46 mmol), DIPEA (16 mL, 89.2 mmol), and benzyl alcohol (5 mL, 44.6 mmol) were added dropwise. The mixture was stirred at room temperature for 12 hours. The mixture was washed several times with an aqueous solution of 5% citric acid. The organic layer was dried over sodium sulfate, and filtered and distilled under reduced pressure to obtain the title compound as yellow oil (6.7 g, 99%).

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