Реакция #162868

Уравнение реакции

tert-butyl carbamate

2-benzyl-2-azabicyclo[2.2.2]octan-6-ol

→

2-benzyl-2-azabicyclo[2.2.2]octan-6-ol

title product

tert-butyl 6-oxo-2-azabicyclo[2.2.2]octane-2-carboxylate

Условия реакции

Методика

2-benzyl-2-azabicyclo[2.2.2]octan-6-ol is prepared using a method analogous to that described in U.S. Pat. No. 5,147,873. 2-benzyl-2-azabicyclo[2.2.2]octan-6-ol is debenzylated and subsequently protected as the tert-butyl carbamate using procedures analogous to those described in Example 1. Oxidation of the resulting intermediate alcohol using the Swern protocol affords the title product.

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