Реакция #162867

Уравнение реакции

Compound 8

(2S)-tert-butyl 2-(4-(4′-(2-((3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-imidazol-4-yl)biphenyl-4-yl)-1H-imidazol-2-yl)octahydro-1H-indole-1-carboxylate

water

→

(2S)-2-(4-(4′-(2-((3S)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-imidazol-4-yl)biphenyl-4-yl)-1H-imidazol-2-yl)octahydro-1H-indole

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеResulting
2. 2
   Другоеreaction
3. 3
   ТемператураThe resulting slurry was cooled to RT
4. 4
   ФильтрацияFiltration of the slurry
5. 5
   Другоеafforded a solid
6. 6
   Промывкаwashed with 15 ml acetone
7. 7
   Другоеdried directly
8. 8
   Другоеused in the next reaction

Методика

Compound 8 were taken in 9 ml methanol; 1 ml Conc. HCL and 0.2 ml water was added. Resulting reaction was stirred for 5 h at 50° C. (oil bath temp) completed, after completion of the reaction monitor by HPLC. The resulting slurry was cooled to RT and held with agitation for about 1H. Filtration of the slurry afforded a solid; washed with 15 ml acetone dried directly used in the next reaction.

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