Реакция #162661

Уравнение реакции

3-chloro-2-methylaniline

compound 26

3-chloro-2-methylaniline

bis(2-chloroethyl)amine hydrochloride

compound 27

bis(2-chloroethyl)amine hydrochloride

Na2CO3

→

title compound

Выход 81.0%

1-(3-chloro-2-methylphenyl)piperazine

Выход 81.0%

Растворители

n-butanol

Условия реакции

Обработка

1. 1
   Температураto refluxed temperature for 2 days
2. 2
   workup.ADDITIONwas added
3. 3
   Другоеreaction mixture
4. 4
   Температураwas refluxed 30 min
5. 5
   ФильтрацияThe resulting mixture was filtered with n-butanol (100 ml)
6. 6
   Другоеcollected solid
7. 7
   Другоеwas dried under reduced pressure

Методика

To a stirred solution of 3-chloro-2-methylaniline (compound 26, 21.6 g, 0.15 mol) in n-butanol (200 ml) was added bis(2-chloroethyl)amine hydrochloride (compound 27, 30 g, 0.17 mol) at room temperature and allowed to refluxed temperature for 2 days. After cooled to room temperature Na2CO3 (9 g, 0.08 mol) was added and then reaction mixture was refluxed 30 min. The resulting mixture was filtered with n-butanol (100 ml) and collected solid was dried under reduced pressure to be obtained title compound (24.8 g, 81%) as a white solid.

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